LANOLIN HYDROUS
Lanolin
CAS: 8006-54-0;8020-84-6
Molecular Formula: N/A
LANOLIN HYDROUS - Names and Identifiers
LANOLIN HYDROUS - Physico-chemical Properties
| Molecular Formula | N/A |
| Density | 0.932-0.945 g/cm3(Temp: 15 °C) |
| Melting Point | 38-40 °C |
| Flash Point | 209 °C |
| Water Solubility | Soluble in ether, petroleum ether, chloroform and petroleum benzene. Sparingly soluble in ethanol. Insoluble in water. |
| Solubility | chloroform: 0.1g/mL, clear to faintly turbid (<29 NTU), strongly yellow-green |
| Appearance | Yellow-like solid |
| Color | White to yellow |
| Merck | 14,5358 |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00081740 |
| Physical and Chemical Properties | Lanolin is a secreted oil that attaches to the wool. There are two types of lanolin refined products, namely, anhydrous lanolin and hydrated lanolin. Lanolin anhydrous light yellow or brown yellow ointment; Viscous and smooth; Odor weak and specific. It is soluble in chloroform or ether, soluble in hot ethanol, very slightly soluble in ethanol, insoluble in water; But it can be mixed with about 2 times the amount of water, and has excellent emulsifying properties. Lanolin is not saponified in caustic, but can be saponified by pressure and heating in an ethanolic solution of caustic. Strong hygroscopicity. Mp36-42 ° C., the acid value is not more than 1.5, the saponification value is 92-106 (the heating reflux time is 2H in the measurement), and the iodine value is 18-35 (the time of standing in the dark is 4H in the measurement). Hydrous lanolin is a pale yellow or off-white ointment containing 25%-35% water which is obtained by mixing the melted lanolin with distilled water. Soluble in ether, chloroform; Insoluble in water. |
| Use | Used as analytical reagents, gas chromatography stationary liquid, rust inhibitor and buffer, also used in the preparation of cosmetics |
LANOLIN HYDROUS - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | OE3201000 |
| TSCA | Yes |
| HS Code | 15050000 |
LANOLIN HYDROUS - Reference
| Reference Show more | 1. By Shuping, Zhao Jun, Ma Long, etc. Effect of ethanol extract of Cistanche deserticola on immune hepatic fibrosis in rats and its mechanism [J]. Chinese Journal of Pharmacology and Toxicology, 2016, 30(05):504-510. 2. Mu-ke-hot-wood-pudimetti, by Shuping, Zhao Jun, et al. Effects of phenylethanoid glycosides from Cistanche deserticola on hepatic fibrosis induced by BSA in rats [J]. Journal of Xinjiang Medical University, 2015. 3. By Shuping, Zhao Jun, Mu kehemu tauditai, Ma Long, Zhang Shi Lei, Liu Tao. Effects of phenylethanoid glycosides from Cistanche deserticola on the expression of transforming growth factor β1 in rats with hepatic fibrosis induced by BSA [J]. Canceration · aberration · mutation, 2015,27(06):409-414. |
LANOLIN HYDROUS - Nature
Open Data Verified Data
This product is light yellow or brown yellow ointment; Viscous and smooth; Weak and specific odor. Soluble in chloroform or ether, soluble in hot ethanol, insoluble in water, but can be mixed with about 2 times the amount of water. The melting point is 36~42 C, the acid value is not more than 1.5, the saponification value is 92~106 (determination of heating reflux time is 2H) iodine value is 18~35. Lanolin is a medicinal matrix extracted from wool washing effluent, which contains about 94% Ester, 1% free alcohol, 1% free fatty acid and 1% saccharide. The goods on the skin permeability, suitable for play a role in the dermis. Since the chemical composition of lanolin is close to the stratum corneum components of human skin and hair in some aspects, especially containing cholesterol compounds with up to 40% hydrophilicity, it can soften and moisturize skin and hair. Lanolin texture is too thick, should not be used alone, need to be combined with Vaseline. Lanolin containing 30% moisture is called hydrous lanolin, and its viscosity is low, which is convenient for application.
Last Update：2024-01-02 23:10:35
LANOLIN HYDROUS - Standard
Authoritative Data Verified Data
This line is obtained by processing and refining wool.
Last Update：2024-01-02 23:10:35
LANOLIN HYDROUS - Trait
Authoritative Data Verified Data
- This product is light yellow to brown yellow wax; Sticky and smooth; Weak and specific odor.
- This product is soluble in chloroform or ether, soluble in hot ethanol, very slightly soluble in ethanol, insoluble in water; But can be mixed with about 2 times the amount of water.
melting point
The melting point of this product (General rule 0612 second method) is 36~42°C.
acid value
The acid value of this product (General 0713) is not more than 1.5.
saponification value
The saponification value of this product (General rule 0713) is 92~106 (heating reflux time is 2 hours when measuring).
iodine value
The iodine value of this product (General rule 0713) is 18~35 (when measured in the dark place for 4 hours).
Last Update：2022-01-01 11:22:16
LANOLIN HYDROUS - Introduction
The addition of refined lanolin and ethylene oxide increases the hydrophilicity with the increase of EO moles. When EO increases to 70-75mol, the product becomes water soluble. PEG-75 lanolin is a light yellow flaky solid with good emollient and conditioning without feeling greasy. Due to its superior water solubility, it is suitable for transparent gels and aqua products. It has excellent stability in the presence of a wide pH value and electrolyte. It can be used as a co-emulsifier in oil-in-water systems.
Last Update：2022-10-16 17:29:01
LANOLIN HYDROUS - Use
Open Data Verified Data
ointment base.
Last Update：2022-01-01 11:14:16
LANOLIN HYDROUS - Differential diagnosis
Authoritative Data Verified Data
take 0.5g of this product, add chloroform 5ml to dissolve, add acetic anhydride lm l and sulfuric acid 2 drops, that is dark green.
Last Update：2022-01-01 11:22:17
LANOLIN HYDROUS - Safety
Open Data Verified Data
sealed and stored in a cool place.
Last Update：2022-01-01 11:14:16
LANOLIN HYDROUS - Exam
Authoritative Data Verified Data
pH
Take 10g of this product, add 50ml of water, heat and melt on a water bath, stir constantly, cool, remove fat, the solution should be clear, take 10M l, add 1 drop of phenolphthalein indicator solution, do not show red; Another 10ml is added with 1 drop of Methyl red indicator solution, which should not show red.
chloride
take 0.20g of this product, put it in an Erlenmeyer flask, add 27ml of ethanol, heat reflux for several minutes, let it cool, and add nitric acid 0.5 m l, filtration, filtrate plus silver nitrate ethanol solution (1-50) 5 drops, such as turbidity, with the control solution [20ml ethanol, plus standard sodium chloride solution 7. 0ml, nitric acid 0.5ml and silver nitrate ethanol solution (1 - 5 0 )5 drops made] comparison, not more concentrated (0. 035).
easy oxide
take 10ml of the solution left under the above pH item, add l drops of potassium permanganate titration solution (0.02 M o L/l), and the red color shall not disappear completely within 5 minutes.
insolubles in ethanol
take this product 0.50g, add ethanol 40ml, boiling, the solution should be clear or slightly turbid.
loss on drying
take this product, dry to constant weight at 105°C, add stirring, loss of weight should not exceed 0831 (general rule).
ignition residue
not more than 0.15% (General rule 0841).
Last Update：2022-01-01 11:22:17
LANOLIN HYDROUS - Category
Authoritative Data Verified Data
pharmaceutical excipients, soft-tone matrix and emulsifier.
Last Update：2022-01-01 11:22:18
LANOLIN HYDROUS - Storage
Authoritative Data Verified Data
sealed and stored in a cool place.
Last Update：2022-01-01 11:22:18
LANOLIN HYDROUS - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | lanolin is a cold cream, anti-wrinkle cream, anti-cracking cream, shampoo cream, conditioner, hair cream, the ideal raw material for the production of skin care products such as lipstick and high grade soap is often used as a water-in-oil emulsifier, which is an excellent moisturizing substance. Lanolin is a product with good water absorption, wettability, lipophilicity, emulsification and dispersion. It is widely used in cosmetics, medicine, leather, agriculture and other industries. |
| preparation | a method of synthesizing refined lanolin by inert gas with water, with crude lanolin hydrolysate-wool acid and lanolin alcohol as raw materials, the following steps are carried out in sequence: 1), take wool acid and lanolin each 50g, potassium hydroxide 0.2g in 250ml single-mouth bottle, the system was continuously fed with N2 at a rate of 1ml/(ml · s) and reacted at 190~200 ℃ for 9H. After cooling to room temperature, lanolin cream solid (lanolin solid product) was obtained, for a 250ml one-mouth bottle as a reaction vessel, the amount of N2 passed into the 250ml one-mouth bottle per second was 250ml. 2) add 25g of sodium chlorite and 50ml of methanol to the lanolin paste solid obtained in step 2), slowly add 5g of 37% hydrochloric acid Dropwise (the temperature in the process of controlled dropwise addition is less than or equal to 70 ℃), decolorizing at 70 ℃ for 2H; 3) in step 2), add 50ml of hot water (water at 50~55 ℃) to the decolorized product, the upper oil phase is separated and washed three times (washing conditions are the same as above). After cooling to room temperature, a light yellow solid product is obtained, which is dried in vacuum (vacuum 0.096Mpa) (at 70 ℃ to constant weight), 96.1g of lanolin was obtained in a yield of 96.1% and an acid value of 0.89. |
| Use | lanolin is used in the preparation of cosmetics, pharmaceutical ointments, and also in the leather and fur industry. Also used as a rust inhibitor and corrosion inhibitor, lanolin is a natural moisture protectant, lanolin to maintain skin moisture, nutrition, lanolin has water absorption, suitable for skin moisturizing, lubricating, soft and other skin care cosmetics, and can be used as soap and soap fatliquor, bath oil, sunscreen and other auxiliary cosmetics; Also used as a dispersant for cosmetic pigments. ointment base. It is an important raw material for advanced cosmetics and medicine. mainly used in the manufacture of advanced oil-proof machinery industry, pharmaceutical industry in the rheumatism cream, zinc oxide plaster, chemical fiber industry of synthetic fiber and synthetic resin, daily chemical industry of anti-cracking paste, chemical fiber industry of synthetic fibers and synthetic resins, daily chemical industry anti-cracking cream, cold cream, high-grade soap. Lanolin contains 20% cholesterol, which can be extracted for the production of hormones in the pharmaceutical industry. Lanolin is a raw material with a long history, and this renewable resource has many potential values. It is widely used in medicine and cosmetics. used as anti-rust additive, lubricant, rubber emulsifier used as analytical reagent, gas chromatography stationary liquid, rust inhibitor and buffer, also used in the preparation of cosmetics Gum Chew. Also as a raw material of edible spices. emulsifier. Anti-foaming agent. Rust inhibitor. Corrosion inhibitors. Pharmaceutical auxiliaries. Cosmetic preparation. Gas chromatographic stationary liquid (the highest temperature is 200 ℃, the solvent is chloroform), the separation and analysis of non polar compounds, ethanol, aromatic and heterocyclic compounds and volatile oil. |
| toxicity | can be used safely in foods (FDA,§ 172.615,2000). |
| production method | the fat substance secreted by the fat-secreting glands of sheep attached to wool, it can be separated by soap or solvent, and then refined. lanolin is the product of the extraction and refinement of the secreted wool oil attached to the wool. The amount of this attachment to lanolin is more than 250,000 t per year worldwide, but the actual recovery is estimated to be only about 20,000 t. Lanolin by raw material processing, extraction, precipitation, evaporation, acid treatment, neutralization, decolorization, distillation, impurity extraction and purification of eight steps. The vast majority of the components of the refined foot is wool acid, the most suitable for all kinds of anti-rust soap, for metal surface rust, its anti-rust performance is stronger than the petroleum sulfonated salts. preparation of crude lanolin product using wool-washing sewage as raw material wool-washing sewage was added with aluminum trichloride to obtain the wool-fat-containing putrid mud, and water was removed to obtain the tart mud. Take 600kg of sludge, add 480kg of benzene, stir while adding, heat at 56 ℃ for 1H, stop stirring, precipitate for 1H, clear and dissolve 6-40% of lanolin in benzene solution, and move into the distillation column, heating distillation to contain lanolin up to 34%, cooling to 40 deg C below release, to lanolin crude product. Wool washing sewage [AlCl3]→ mud [benzene, 30 ℃]→ preparation of crude lanolin and neutralization of benzene fat take crude lanolin 2100kg and put it into reaction pan, heat it to 50 ℃, then add the hot 50%(g/g) sulfuric acid solution to the crude lanolin product, stir for 45min, precipitate for half an hour, release the lower feet, add light ethanol to the benzene fat layer, and add water, heat preservation 60 deg C, stirring for half an hour, precipitation for half an hour, release the lower foot, acid treatment of benzene fat. Add 180kg of acid-treated benzene fat and ethanol, gradually add about 70kg of 300g/L sodium hydroxide solution, adjust pH to 9, add 180kg of water, keep the temperature at 60 ℃, and keep stirring from adding ethanol to the end of adding water, then continue stirring for 10min, let stand, precipitate for 1H, release the lower foot, add light ethanol to the benzene lipid layer, stir, precipitate for 1H, release the lower foot, to neutralize the benzene lipid. Lanolin crude [sulfuric acid, water] → [light ethanol] acid treatment of benzene Ester [60 ℃, ethanol] →[NaOH, h2O] neutralization of benzene fat medicinal lanolin product preparation of neutralization of benzene fat, add 3.8% hydrogen peroxide 24kg, stirring, heat preservation 60 ℃, precipitation 35min, release the lower foot, maintain pH8-9, add light ethanol, precipitate for 2H, release the lower foot, to be refined benzene fat. Distillation, liquid temperature of 110 ℃ vacuum evaporation to not distilled, cooling to 60 ℃, adding ethanol, stirring, precipitation for 1H, separation of lower lanolin, adding ethanol, heating and stirring for 10min, discard ethanol, ethanol was distilled off under reduced pressure, and silk cloth was filtered to obtain medicinal lanolin product. Neutralization of benzene fat [H2O2, ethanol, 60 ℃]→ refined benzene fat [ethanol, 110 ℃]→ lanolin finished product. |
| spontaneous combustion temperature | 833 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:54:55
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Product Name: Lanolin Request for quotation
CAS: 8006-54-0
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